Please use this identifier to cite or link to this item: http://ecampus.poltekkes-medan.ac.id/xmlui/handle/123456789/1898
Title: Transforming Growth Factor Expression (TGF-β) Correlate with Serum Level of Malondialdehyde (MDA) after EVOO Administration in Preclinical Rat Models of Preeclampsia
Authors: Syafruddin, Ilyas
Hutahaean, Salomo
Irianti, Evi
Keywords: Apoptosis
Reactive Oxygene Species (ROS)
Issue Date: 2018
Publisher: ICBSB IOP Publishing
Series/Report no.: Ser.: Earth Environ;Sci. 130 012048
Abstract: Preeclampsia can cause cell death either apoptosis or necrosis. One cause is the disturbance of the emergence of malondialdehyde (MDA). Very few reports on the role of Transforming Growth Factor Expression (TGF-β) in the remodeling process of placental cells and their association with serum MDA content. Research of true experiment with complete randomized design (CRD) with five treatment groups. The first group, preeclampsia negative control (T0). The second group, preeclamptic rats model (T1). The third group, preeclamptic rats model+EVOO 0.45g/kg-Body Weight/day (T2). The fourth group, preeclamptic rats model+EVOO 0.90g/kg-BW/day (T3). The fifth group, preeclamptic rats model+EVOO 1.8 g/kg-BW/day (T4). The results showed a significant effect of EVOO on TGF-β expression in preeclampsia rats, meaning that there was a role of TGF-β against pre-eclampsia placenta remodeling. There was a positive and strong relationship (r=0.494) as well as a very significant relationship (p<0.01) between TGF-β and the serum MDA.
URI: http://poltekkes.aplikasi-akademik.com/xmlui/handle/123456789/1898
ISSN: doi :10.1088/1755-1315/130/1/012048
Appears in Collections:Koleksi Jurnal

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