The Role of EVOO (Extra Virgin Olive Oil) in Serum MDA Concentration and Blood Pressure of Pregnant Mice (Rattus norvegicus) with Pre-eclampsia

Abstract

One possible mechanism of failure in spirals artery remodeling is the imbalance between free radicals and antioxidants, which is shown in increasing amount of plastic MDA. The objective of this study is to bring evidence on highly tocopherol (vitamin E) content of extra virgin olive oil (EVOO) in preventing that imbalance. This laboratory study was carried out following post test with control group design. This study involved 25 mice of Sprague Dawley with an approximate weight of 200g which is classified into two groups; control (P0), and experimental group (P1, P2, P3, P4) that are set to have pre-eclampsia. This experimental group were administered 3ml/day of NaCl, 6% on day 6th– 12th of gestation and was given an acute stress on the day 18th of gestation and among the experimental groups, P1 which was not given any dose of EVOO from day 13th – 19th. On day 20th of gestation, all mice were executed. Generally, the concentration of serum MDA was seen to decrease after the administration EVOO (P < 0.05). Significant decrease in systole was also noticed, particularly in groups that received EVOO regiment (P0: P value 0.104, P1:P value 0.498, P2:P value 0.043, P3: P value 0.043, P4: P value 0.043). Finally, from the study, we found that EVOO is able to tackle free radicals down. We also suggested that other antioxidants, such as GPx, SOD and catalase are also studied extensively in the future to get a better understanding about alteration of antioxidants during pregnancy regarding the administration of EVOO.