THE EFFECTS OF PEPINO (Solanum muricatum) EXTRACT TO THE DECREASE OF GLUCOSE CONTENT IN BLOOD OF WHITE RATS Ratus novergicus)

Abstract

The developing countries face the health problem. One of them is degenerative disease. The prevalence of diabetes mellitus in the world is increase drastically in the last decade and it estimate this number is increase in the future In Indonesia, it increase from 2.5 million in 1994 to be five million in 2010. Manganese mineral in pepino has function as anti diabetic, in addition to the content of –sitosterol and stigma sterol as active compound as anti hyperglycemia on pepino extract. This research aims to study the influence of pepino extract to the decrease of glucose content in blood of white rats. The population in this research is white rats (Rattus norvegicus) and sample in this research is 16 white rats. This research is experimental study. The collected data was primary data by take the data of experiment result, i.e. data of measurement of beginning blood glucose content and end blood glucose content of the white rats using digital glucose test. Based on the results of statistical test using Anova test, the value of p (0.000) < α (0.05), it means that there is an influence of pepino extract to the decrease of blood glucose content on white rats. The result of analysis by Duncan test, the application of pepino extract will decrease the blood glucose contant for 67.5 mg/dl. The application of pepino extract for 1 ml/day during 2 weeks will decrease the blood glucose content for 67.5 mg/dl